Welcome from the Center Director

Hossein Najmabadi 

Post-doc: UCLA (USA) 

PhD: University of North Texas (USA) 


Director and Founder, GeneticsResearch Center (GRC) 

e-mail: hnajm12@yahoo.com


Tel. No.: 0098-21-22180138

Address: Genetics Research Center- University of Social Welfare and Rehabilitation- Kudakyar Alley- Daneshju Blvd.- Evin- Tehran- Iran

Link in scopus: http://www.scopus.com/authid/detail.url?origin=resultslist&authorId=6701918454&zone=

Link in google scholar: https://scholar.google.com/citations?user=YVvoh6IAAAAJ&hl=en


Research Interests 

The mandate of the GRC, also designated the National Reference Laboratory for Prenatal Diagnosis in Iran, is to prevent genetic disabilities and disorders by the establishment of a nationwide strategy for the early prenatal diagnosis of genetic disorders. In five areas of preventable genetic  disorders,  Dr.  Najmabadi  leads  projects that  not  only  apply preventive solutions within the population but also involve nationallyand internationally collaborative research in order to improve the quality of life nationwide. 


Current Projects

GRC  research  on  cognitive  dysfunction  in  particular  mental  retardation  (MR)  includes the  evaluation  of  clinical  heterogeneity  of MR patients  either  syndromic  or  nonsyndromic and the establishment of genetic causes using cytogenetics, molecular genetics techniques. The investigation of hemoglobinopathies at the GRC comprises a number of projects  to  identify  the  mutation  spectrum  of  alpha-  and beta-thalassemia,  with  the establishment of protocols for mutation identification and prenataldiagnosis. Moreover, studies  on  the  potential elements  in  the  induction  of  gamma  globin  as  well  as  the molecular mechanism of hydroxyurea aim to improve the treatment of thalassemia. In the study  of  both  syndromic  and  non-syndromic  deafness, the GRC identifies the genes or mutations  particular  to  Iran and  establish diagnostic  protocols  for  them.  In  order  to classify  different  subtypes  of  neuromuscular  disorders  (NMD)  in  Iran, family  DNA studies are guided by the histopathology facilities at the GRC. 

Selected publications 

Kahrizi K, Mohseni M, Nishimura C, Bazazzadegan N, Fischer SM, Dehghani A, Sayfati M, Taghdiri M, Jamali P, Smith RJ, Azizi F, Najmabadi H. Identification of SLC26A4 gene  mutations  in  Iranian  families  with  hereditary  hearing  impairment.  Eur  J  Pediatr. 2009;168(6):651-3. 

A.W.  Kuss,  M.  Garshasbi,  K.  Kahrizi,  A.  Tzschach,  F.  Behjati,  H.  Darvish,  L.  Abbasi Moheb, L. Puettmann, A. Zecha, R. QWeob,amm. H. Hu. M. Mohseni, S.S. Abedini, A. Rajab,  Ch.  Hertzberg,  D.  Weiczorek,  R.Ullmann, S. Ghasemi-Firozabadi,  S. Banihashemi, S. Arzhangi, v. Hadavi, Gh. Bahrami-Monajemi, M. Kasiri, M. Falah, P. Nekoei,  A.  Dehghan,  M.  Sobhani,  P.  Jamali,  H.H.  Ropers,  H.  Najmabadi. Autosomal recessive  mental  retardation:  homozygosity  mapping  identifies  27  single  linkage intervals,  at  least 14  novel  loci  and several  mutation  hotspots.  Human  Genetics;[Epub ahead of print]. 

Darvish  H,  Esmaeeli-Nieh  S,  Monajemi GB,  Mohseni  M,  Ghasemi-Firouzabadi  S, Abedini  SS,  Bahman  I,  Jamali  P,  Azimi  S,  Mojahedi F,  Dehghan  A,  Shafeghati  Y, Jankhah A, Falah M, Soltani Banavandi MJ, Ghani-Kakhi M, Garshasbi M, Rakhshani F, Naghavi  A,  Tzschach A,  Neitzel  H,  Ropers  HH,  Kuss  AW,  Behjati  F,  Kahrizi  K, Najmabadi  H.  A  clinical  and  molecular  genetic  study  of  112  Iranian families  with primary microcephaly. J Med Genet. 2010;47(12):823-8. 

Pouya  AR,  Abedini  SS,  Mansoorian  N,  Behjati  F,  Nikzat  N,  Mohseni  M,  Nieh  SE, Abbasi L, Darvish H, Monajemi GB, Banihashemi S, Kahrizi K, Ropers HH, Najmabadi H.  Fragile  X  Syndrome  Screening  of  Families  with  Consanguineous  and  Nonconsanguineous Parents in the Iranian Population. Eur J Med Genet. 2009;52(4):170-3. 

Shearer  AE,  Hildebrand  MS,  Webster  JA,  Kahrizi  K,  Meyer  NC,  Jalalvand  K, Arzhanginy S, Kimberling WJ, Stephan D, Bahlo M, Smith RJ, Najmabadi H. Mutations in  the  first  MyTH4  domain  of  MYO15A are  common  cause  of  DFNB3  hearing  loss. Laryngoscope. 2009;119(4):727-33.  




Genetics Research Center
Iranome: Iranian Genomic Variations

The human genome is highly variable and each individual’s genome contains approximately 3.5 million Single Nucleotide Polymorphisms (SNPs) and 1000 large (>500 bp) Copy Number Variations (CNVs).

Today, large scale projects such as the 1000 Genomes and the International HapMap projects have been implemented on large scale samples from different populations such as Europeans, Americans, East Asians, and sub-Saharan Africans to increase our understanding of the contribution of genomic variations to human diseases. … more