17/11/2017
آمار بازدید
 total : 76422
 online : 4
Dr. Mehdi Banan
 

Mehdi Banan

PhD: University of Texas at Austin

Associate Professor

e-mail: mbbanan@yahoo.com

           me.banan@uswr.ac.ir

Tel. No.: 0098-21-22180138

Address: Genetics Research Center- University of Social Welfare and Rehabilitation- Kudakyar Alley- Daneshju Blvd.- Evin- Tehran- Iran

Link in scopus: http://www.scopus.com/authid/detail.url?origin=AuthorProfile&authorId=55404728100&zone=

Link in google scholar: https://scholar.google.com/citations?user=55mvY10AAAAJ&hl=en&oi=ao

 

Research Interests:

We are interested in understanding the differential response of β-thalassemia patients to the γ-globin inducing drug, hydroxyurea. We are also trying to understand why the severity of the β-thalassemia disorder varies between patients i.e. phenotype/genotype studies.

 

Current Projects:

Understanding the possible functional role of tag SNPs located in the BCL11A enhancer by using genome editing technology (CRISPR-Cas9) in model cell lines. 

 

Selected publications:

Banan M*, Esmaeilzadeh-Gharadaghi E, Nezami M, Deilami Z, Farashi S, Philipsen S, Esteghamat F, Pourfarzad F, Imam AMA, and  Najmabadi H (2012) cAMP response element protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells. Clin Exp Pharmacol Physiol. 39(6): 510-517. 

Banan M*, Bayat H, Azarkeivan A, Mohammadparast S, Farashi S, Hadavand-Khani M, Neishabury M, and Najmabadi H (2012) The XmnI and Bcl11A single nucleotide polymorphisms may help predict hydroxyurea response in Iranian β-thalassemia patients. Hemoglobin 36(4): 371-380.

Banan M (2013) Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond? Ann Hematol. 92: 289-299.

Banan M*, Bayat H, Namdar-Aligoodarzi P, Azarkeivan A, Kamali K, Daneshmand P, Zaker-Kandjani B, and Najmabadi H (2013) Utility of the multivariate approach in predicting intermedia or β-thalassemia major types in Iranian patients. Hemoglobin 37(5):  413-422.

Zaker-Kandjani B, Namdar-Aligoodarzi P, Azarkeivan A, Najmabadi H, and Banan M* (2015) Mutation screening of the Krüppel-Like Factor 1 gene by using single-strand conformation polymorphism in a cohort of Iranian β-thalassemia patients. Hemoglobin 39(1): 24-29.

more

 

http://genetic.uswr.ac.ir/index.jsp?siteid=60&fkeyid=&siteid=60&pageid=9761

 

 

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