Welcome from the Center Director
PhD: University of Texas at Austin
Tel. No.: 0098-21-22180138
Address: Genetics Research Center- University of Social Welfare and Rehabilitation- Kudakyar Alley- Daneshju Blvd.- Evin- Tehran- Iran
Link in google scholar: https://scholar.google.com/citations?user=55mvY10AAAAJ&hl=en&oi=ao
We are interested in understanding the differential response of β-thalassemia patients to the γ-globin inducing drug, hydroxyurea. We are also trying to understand why the severity of the β-thalassemia disorder varies between patients i.e. phenotype/genotype studies.
Understanding the possible functional role of tag SNPs located in the BCL11A enhancer by using genome editing technology (CRISPR-Cas9) in model cell lines.
Banan M*, Esmaeilzadeh-Gharadaghi E, Nezami M, Deilami Z, Farashi S, Philipsen S, Esteghamat F, Pourfarzad F, Imam AMA, and Najmabadi H (2012) cAMP response element protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells. Clin Exp Pharmacol Physiol. 39(6): 510-517.
Banan M*, Bayat H, Azarkeivan A, Mohammadparast S, Farashi S, Hadavand-Khani M, Neishabury M, and Najmabadi H (2012) The XmnI and Bcl11A single nucleotide polymorphisms may help predict hydroxyurea response in Iranian β-thalassemia patients. Hemoglobin 36(4): 371-380.
Banan M (2013) Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond? Ann Hematol. 92: 289-299.
Banan M*, Bayat H, Namdar-Aligoodarzi P, Azarkeivan A, Kamali K, Daneshmand P, Zaker-Kandjani B, and Najmabadi H (2013) Utility of the multivariate approach in predicting intermedia or β-thalassemia major types in Iranian patients. Hemoglobin 37(5): 413-422.
Zaker-Kandjani B, Namdar-Aligoodarzi P, Azarkeivan A, Najmabadi H, and Banan M* (2015) Mutation screening of the Krüppel-Like Factor 1 gene by using single-strand conformation polymorphism in a cohort of Iranian β-thalassemia patients. Hemoglobin 39(1): 24-29.
The human genome is highly variable and each individual’s genome contains approximately 3.5 million Single Nucleotide Polymorphisms (SNPs) and 1000 large (>500 bp) Copy Number Variations (CNVs).
Today, large scale projects such as the 1000 Genomes and the International HapMap projects have been implemented on large scale samples from different populations such as Europeans, Americans, East Asians, and sub-Saharan Africans to increase our understanding of the contribution of genomic variations to human diseases. … more