Welcome from the Center Director
PhD: University of Wales (UK)
Tel. No.: 0098-21-22180138
Address: Genetics Research Center- University of Social Welfare and Rehabilitation- Kudakyar Alley- Daneshju Blvd.- Evin- Tehran- Iran
Link in google scholar: https://scholar.google.com/citations?hl=en&user=h-7qYFgAAAAJ&view_op=list_works
Our research interest includes mechanism of hemoglobin switching, with a special focus on phenotype modifying factors in thalassemia. We are currently working on protein- DNA interactions between beta globin locus control region and transcription factors involved in regulation of beta globin gene cluster.
Current Research Project:
Comparing the binding affinity of RUNX1 transcription factor for two oligonucleotides, representing the single nucleotide polymorphism at the palindromic sequence of 5'HS4- Beta globin Locus Control Region
Neishabury, M., S. Zamani, A. Azarkeivan, S. S. Abedini, H. Darvish, F. Zamani & H. Najmabadi (2012) The modifying effect of Xmn1-HBG2 on thalassemic phenotype is associated with its linked elements in the beta globin locus control region, including the palindromic site at 5'HS4. Blood Cells Mol Dis, 48, 1-5.
Weatherall, D. J. (2012) Commentary on "The modifying effect of Xmn1-HBG2 on thalassemic phenotype is associated with its linked elements in the beta globin locus control region, including the palindromic site at 5' HS4" by M. Neishabury et al. Blood Cells Mol Dis, 48, 6.
Neishabury, M., F. Zamani, E. Keyhani, A. Azarkeivan, S. S. Abedini, M. S. Eslami, S. T. Kakroodi, M. J. Vesiehsari & H. Najmabadi (2013) The influence of the BCL11A polymorphism on the phenotype of patients with beta thalassemia could be affected by the beta globin locus control region and/or the Xmn1-HBG2 genotypic background. Blood Cells Mol Dis, 51, 80-4.
Talebi Kakroodi, S., Jafari Vesiehsari, M., Abedini, S., Ghobakhloo, S., Dehghani, H., Keyhani, e., Azarkeivan, A., Zamani, F., Najmabadi, H., Neishabury,M (2015) The role of BCL11A and HBS1L-MYB polymorphisms in predicting blood transfusion requirements of thalassemia patients with homozygous 5’HS4-LCR/Xmn1-HBG2 background. Genetis in the third millenium, 13, 3990-3993.
The human genome is highly variable and each individual’s genome contains approximately 3.5 million Single Nucleotide Polymorphisms (SNPs) and 1000 large (>500 bp) Copy Number Variations (CNVs).
Today, large scale projects such as the 1000 Genomes and the International HapMap projects have been implemented on large scale samples from different populations such as Europeans, Americans, East Asians, and sub-Saharan Africans to increase our understanding of the contribution of genomic variations to human diseases. … more